Follow Our Work
Free reports based on interviews with working scientists.
Interview No. 3
Induced Pluripotent Stem Cells (iPSCs)
How are haplobanking and genome editing addressing immunogenicity challenges for future iPS cell therapy?
With YAMANAKA Shinya (山中 伸弥), HOTTA Akitsu (堀田 秋津), HANATANI Tadaaki (花谷 忠昭), YOSHIDA Shinsuke (吉田 信介), and DOHI Hiromi (土肥 浩美)
Topics: Hypoimmunity strategies, clinical-grade HLA-homozygous iPSC line biomanufacturing, HLA-C-retained CRISPR-cas9 knockouts, xenograft immunogenicity testing, custom sgRNA design, reprogramming challenges (undifferentiated marker expression, chromosome 11 uniparental disomy, residual plasmids)
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Interview No. 2
Induced Pluripotent Stem Cells (iPSCs)
What are the basic and translational imperatives in pluripotency and reprogramming research?
With YAMANAKA Shinya (山中 伸弥), Steven FINKBEINER, Bruce CONKLIN, Benoit BRUNEAU, and TOMODA Kiichiro (友田 紀一郎).
Topics: Reprogramming efficiency enhancement, cocktail choice, episomal plasmids, reproducible differentiation, GMP-grade production, the Waddington landscape, transdifferentiation, translation-initiation factors, CiRA/Gladstone, etc.
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